Harry Kane missed out on the previous squad through injury, but made a goalscoring return from his seven-week absence during Tottenham Hotspur’s 1-1 draw with Arsenal in the North London derby this afternoon.
Jack Wilshere, meanwhile, recently completed 90 minutes in the Premier League for the first time since 2014, and the
Bournemouth loanee is rewarded with a place in the 25-man squad for the international double-header.
Tom Heaton , Ryan Bertrand , Nathaniel Clyne , Phil Jagielka, Danny Drinkwater , Adam Lallana and Raheem Sterling all also return having missed the World Cup qualifiers against Malta and Slovenia through injury.
Uncapped Michael Keane retains his place in the squad, meanwhile, while the likes of Alex Oxlade-Chamberlain, Kieran Gibbs and Michail Antonio miss out.
Tottenham’s Dele Alli is sidelined through injury, as is Manchester United defender Chris Smalling .
England will face Scotland in a World Cup qualifier at Wembley on Friday before hosting Spain in a friendly for their final match of 2016.
The games are scheduled to be Southgate’s last two in interim charge of the team, with the FA expected to appoint a permanent successor before their next scheduled match against Germany in March.
England squad to face Scotland and Spain:
Goalkeepers: Fraser Forster (Southampton), Joe Hart (Torino, loan from Manchester City), Tom Heaton (Burnley)
Defenders: Ryan Bertrand (Southampton), Gary Cahill (Chelsea), Nathaniel Clyne (Liverpool), Phil Jagielka (Everton), Michael Keane (Burnley), Danny Rose (Tottenham Hotspur), John Stones (Manchester City), Kyle Walker (Tottenham Hotspur)
Midfielders: Eric Dier (Tottenham Hotspur), Danny Drinkwater (Leicester City), Jordan Henderson (Liverpool), Jack Wilshere (AFC Bournemouth, loan from Arsenal), Adam Lallana (Liverpool), Jesse Lingard (Manchester United), Wayne Rooney (Manchester United), Raheem Sterling (Manchester City), Andros Townsend (Crystal Palace)
Forwards: Theo Walcott (Arsenal), Harry Kane (Tottenham Hotspur), Marcus Rashford (Manchester United), Daniel Sturridge (Liverpool), Jamie Vardy (Leicester City)