Ibrahim Afellay, 31, is unlikely to play any further part in a campaign in which he has only played 13 times.
“Unfortunately Ibrahim Afellay has a bit of a problem with his knee and is likely to be out for four or five weeks,” manager Mark Hughes said at a news conference.
“He has gone back to Barcelona to see the surgeon who has worked with him before and has undertaken a small operation.
“There was a little problem in his knee but hopefully the procedure will help clear that up.
“With there only being six games of the season left it is unlikely that he will feature again unfortunately, but we will wait and see about that.”
Afellay has been plagued by injury throughout his career and only recently returned from a serious knee injury, having previously experienced a similar problem during his time at Barcelona.