The franchise, yet to be named, will compete in the North American Soccer League (NASL), the second tier, from 2018.
The Belgium star, along with Crystal Palace’s Yohan Cabaye, Moussa Sow of Al Ahli and Hazard’s former Chelsea team-mate Demba Ba, have combined with local business executives to invest in a new club in San Diego.
Drogba, another of Hazard’s ex Chelsea colleagues, broke new ground in April in becoming player-owner of Phoenix Rising, who compete in a rival second tier, the United Soccer League.
“San Diego is a beautiful place and the love and passion the people have for soccer made this an easy choice for us,” Hazard said.
“My friends and I are honoured to turn this dream into a reality and we can’t wait to get started and win some games.”