Zlatan Ibrahimovic, 34, has been granted a holiday by Manchester United manager Jose Mourinho, and will therefore play no part as the Red Devils welcome the Ukrainian minnows to Old Trafford.
Ibrahimovic flew to Italy on Monday after helping his side to a 4-1 victory over Premier League champions Leicester City at the weekend, spending his holiday time in Milan.
Mourinho will also be without Anthony Martial and Luke Shaw for the match, while Phil Jones remains sidelined with a knee ligament injury.
However, the hosts are expected to be boosted by the return of Henrikh Mkhitaryan , who has missed the last four games with a thigh problem.
United are currently bottom of Group A following their 1-0 defeat to Feyenoord on matchday one.