Having overcome reigning champion Jelena Jankovic in the semi-final, fifth seed Wozniacki played with an assuredness that had for so long been missing from the former world number one’s game.
After surviving a break-point scare in the opening game, Wozniacki broke at the first two opportunities to surge into a 5-0 lead.
Mladenovic eventually got on the board, but it only delayed the inevitable.
The Frenchwoman took a medical time-out before holding serve in the opening game of second set, with the world number 54 showing some discomfort in her right hamstring.
She returned to apply pressure in a see-saw second set which included a run of four consecutive breaks of serve.
Wozniacki finally steadied the ship and took it to a tie-break, where Mladenovic’s growing confidence was evident in her aggressive approach to points, which saw her level the match.
But Mladenovic’s injury problems returned with a vengeance in the decider as she struggled to serve, allowing Wozniacki to seize the initiative and secure her 25th WTA title, while her opponent was left in tears.