Owen Farrell has missed the opening six matches of the Premiership season with back and hip problems.
Alex Lozowski has proved an able deputy in the England fly-half’s absence, scoring four tries and contributing a total of 66 points after joining from Wasps during the close season, but Mark McCall’s first-choice number 10 will make his return at Stade Mayol.
Brad Barritt captains a side that also includes Alex Goode, Maro Itoje and Billy Vunipola in a match between the last two European champions.
Flanker Jackson Wray will make his 150th appearance for the club.
Saracens XV in full: Alex Goode, Sean Maitland, Marcelo Bosch, Brad Barritt, Chris Wyles, Owen Farrell, Richard Wigglesworth; Mako Vunipola, Jamie George, Juan Figallo, Maro Itoje, George Kruis, Jackson Wray, Schalk Burger, Billy Vunipola.
Replacements: Schalk Brits, Richard Barrington, Petrus Du Plessis, Jim Hamilton, Michael Rhodes, Ben Spencer, Alex Lozowski, Mike Ellery.